I think u should not do it as u are not sure about the radiation induced chromosome damages.... There are some studies in mutation research letters like the one below
http://www.sciencedirect.com/science/article/pii/0165799295900659
I don't think that this method of sterilization would be appropriate for blood. I believe, but don't have any supporting data, that sterilization doses that are typically required for inanimate objects such as syringes, is very high. Bacteria are pretty resistant to radiation whereas blood components are probably quite sensitive. I would guess that radiation-sterilized blood would not be well received by the general public either. I won't even consume radiation sterilized meat.
Dear Russak
Thanks for your interesting comments.but as we know that the blood components (RBC, WBC, & PLT) have different response to nuclear radiation eadpecualy for alpha particles. Therefore , to reduce blast cells optimum radiation dose and time of irradiation ( invit to) are very important
Thanks
I'm not sure if you are suggesting the use of internal alpha radiation, but if so I would think that the blood would lose all of its functionality. External alphas would have a hard time penetrating any blood containment vessel and would not work either. I believe that radiation induced sterilization utilizes high dose gammas from large external sources, at least for non living items, such as syringes and other medical devices.
There is a company in the US named Sanuave Health located in Alpharetta, Georgia that uses shock wave technology for killing bacteria and viruses. Not sure if you want to sterilize blood for use as a culture medium or for transfusion, but you might want to check this company out.
I am not familiar with ionizing radiation sterilization of blood, but that of some tissue allografts is recently reviewed in
https://www.ncbi.nlm.nih.gov/pubmed/27158422 (PDF freely downloadable).
Pathogen reduction treatment based on riboflavin and UVC (ultraviolet light C) may also be interesting.
https://www.ncbi.nlm.nih.gov/pubmed/27001363
https://www.ncbi.nlm.nih.gov/pubmed/26643781
- Badges
- Science method
- Similar topics
- Biological Science
- Ecology