Dear Pranav,

The dogma has always been that AAV, particularly single-stranded AAV, takes many days to switch on. However in our experience, expression is detectable within 24 hours and, for luciferase at least, is hitting peak expression by 3 days after neonatal i.v. or i.c. delivery.

BW, Simon

Thanks a lot for the suggestion Simon.

I was more of the opinion that the expression invivo would take more time , maybe about 10-14 days.

Probably for adult organisms , it might vary depending on which area do you inject.

The timecouse of gene expression using AAV vector in vivo can be more than 6months. But what we find out is that is different with different serotype of aav.

• You can read the description detailly in the AAV page in http://www.genemedi.net/i/aav-packaging
• Anyone can also send message to me for AAV production and AAV evolution.