the elecyrolyte of sodium concentration may be detected the saliva flow rate
Sodium ion concentration - Isonisity for gland - Following .
Dear Dr.
The concentrations of electrolytes, proteins and neutral molecules are relative and depend largely on the behavior of their solvent i.e. water.
After its formation in the acinus region the primary saliva passes the striated duct and the main ductuli of the salivary gland (the secretory unit). The striated duct has an active lining where sodium reabsorption takes place in exchange for potassium. Some water uptake from the saliva may also be expected. While the primary saliva has electrolyte concentrations near to blood values, low sodium concentrations are apparent after its passage of the striated. Depending on the flow rate the sodium concentration varies from 75 mmol/l after stimulation to 1 mmol/l in rest. The overall outcome is reflected in a decreasing osmolality from 100 mmol/kg to 40 mmol/kg in rest. These changes are highly demanding for the distal ductal epithelial lining. Normally it should be impermeable to small solutes and even to water. Slightly damaging as in inflammation will immediately result in an osmotic gradient with fluid transport to the interstitium.
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