Disruptions in the mitochondrial ROS - HIF1alpha - Kv1.5 pathway has been the central focus in causing pulmonary vasoconstriction. How would starving a cell of proline-rich peptide formation via tRNA synthetase inhibitor affect the TCA cycle and ROS production?
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Please you look at this article:
Article Reactive Oxygen Species Formation in the Brain at Different ...
HIF activation during hypoxia ensures optimum ATP production and cell integrity, and is associated both directly and indirectly with reactive oxygen species (ROS) formation. HIF activation can either reduce ROS formation by suppressing the function of mitochondrial tricarboxylic acid cycle (TCA cycle), or increase ROS formation via NADPH oxidase (NOX), a target gene of HIF pathway.