Same drug and dosage was tested in MCT and SuHx PAH rat models but exhibited suppression of vascular remodeling in the MCT model only. What may contribute to this difference in results?
For a drug that is practically insoluble in water and sparingly soluble in ethanol and DMSO, how may each of the following factors be manipulated to maximize the drug exposure when applied into a...
17 April 2022 4,704 1 View
If a drug that's known to inhibit STAT3 and cause mitochondrial uncoupling results in cytotoxicity that is unique to SU-DHL-1 cell line but not in other cancer cells, what may be the reason for this?
28 October 2021 3,247 2 View
If a particular compound is able to induce STAT3 degradation in SU-DHL-1(lymphoma) and K562(lymphoblast) cell lines but not in KG-1(bone-marrow) cell line, what may be the cause of it? How is...
12 September 2021 8,162 1 View
The concept of using the innate UPS system is very interesting and new to me. It seems like most PROTAC E3 ligases consist of ligands for cereblon. If I were to use a different E3 ligase other...
24 March 2021 7,023 1 View
Disruptions in the mitochondrial ROS - HIF1alpha - Kv1.5 pathway has been the central focus in causing pulmonary vasoconstriction. How would starving a cell of proline-rich peptide formation via...
11 March 2021 9,180 1 View
I need to examine the in vitro antiviral activity of a drug in the presence of a series of dilutions of human serum up to 40 percent (e.g., 5 percent, 10 percent, 20 percent, 40 percent). An...
01 February 2021 2,167 1 View
I'm in need of a reference or a method to come up with a protocol that allows one to get the protein-adjusted EC50 for an antiviral drug in presence of human serum albumin and acid glycoprotein.
27 January 2021 1,659 1 View
All literature data I came across showed that Ribavirin had equal if not greater effect in titer reduction, survivability, and body weight loss compared to Oseltamivir. The biggest difference I...
03 December 2020 2,445 2 View
I can fathom the idea of PK being different b/w dogs and rodents, but why would I be seeing a significantly different PK profile for the same drug tested on rats and mice?
10 September 2020 8,966 5 View
Some drugs appear to be more quickly absorbed by the body with smaller particle size while some undergo better sustained release with larger particles. Why? Is it related to the absorption...
11 August 2020 6,884 5 View
I am Looking for a Science Journal with good impact factor and low publication cost to publish a review paper. Your suggestions would be appreciated.
06 August 2024 6,796 3 View
I am working on Abaqus/Explicit(Quasistatic ) for the deformation of the auxetic structure model. Please explain how the plastic input value should be considered from the true stress-strain curve...
05 August 2024 454 3 View
A Markov-like Model for Patient Progression" Markov Chain Monte Carlo (MCMC) Markov Chain Monte Carlo (MCMC) is a powerful computational technique used to draw samples from a probability...
05 August 2024 10,079 0 View
Hi everyone, If you have written or come across any papers where Generalised Linear Mixed Models are used to examine intervention (e.g., in mental health) efficacy, could you please share the...
04 August 2024 4,130 4 View
I haven't seen one in a while so I wondered if that journal prohibits that form of redistriibution.
04 August 2024 5,137 3 View
I am working on a SEM model where i have 7 latent variables (6 exogenous and 1 endogenous). In AMOS when I co-vary the exogenous constructs, only 2 paths are coming significant out of 6. But when...
03 August 2024 6,028 4 View
Hi guys If anyone is currently working on aging cells, you guys would like to give me some advice. I'm testing against biomarker (SA-beta-Gal), I encountered a false positive in the control group...
02 August 2024 6,735 1 View
I am an Mphil research student and looking for high impact factor battery related journals to download and read research articles to improve my knowledge and get new ideas in the field of battery...
01 August 2024 6,516 2 View
I have been publishing the Nepalese Journal of Agricultural Sciences (online ISSN 2091-0428; print ISSN 2091-042X) on www.nepjas.com and research gate. I was wondering how I can get an impact...
01 August 2024 1,277 1 View
Is the peer-reviewed publication "MedieKultur: Journal of Media and Communication Research" (ISSN Online: 1901-9726, ISSN Print: 0900-9671) a legitimate and credible scholarly journal in the field...
01 August 2024 629 3 View