Min Gui Jang

11 Questions 2 Answers 0 Followers

Questions related from Min Gui Jang

What are some ways to alter pharmacokinetics of an insoluble drug?

For a drug that is practically insoluble in water and sparingly soluble in ethanol and DMSO, how may each of the following factors be manipulated to maximize the drug exposure when applied into a...

18 April 2022 4,676 1 View

How is NPM-ALK+ lymphoma cell line different from other cancer cells?

If a drug that's known to inhibit STAT3 and cause mitochondrial uncoupling results in cytotoxicity that is unique to SU-DHL-1 cell line but not in other cancer cells, what may be the reason for this?

29 October 2021 3,209 2 View

How is STAT3 degradation regulated in our body and how its expression may differ between various cell lines?

If a particular compound is able to induce STAT3 degradation in SU-DHL-1(lymphoma) and K562(lymphoblast) cell lines but not in KG-1(bone-marrow) cell line, what may be the cause of it? How is...

13 September 2021 8,132 1 View

PROTAC: If I were to employ a tissue specific E3 ligase, can I only target the proteins in that same tissue?

The concept of using the innate UPS system is very interesting and new to me. It seems like most PROTAC E3 ligases consist of ligands for cereblon. If I were to use a different E3 ligase other...

25 March 2021 7,000 1 View

How would starving a cell of amino acids in pulmonary hypertension lead to activation of Kv1.5?

Disruptions in the mitochondrial ROS - HIF1alpha - Kv1.5 pathway has been the central focus in causing pulmonary vasoconstriction. How would starving a cell of proline-rich peptide formation via...

12 March 2021 9,165 1 View

Difference between assessing EC50 in presence of physiological levels of human serum albumin and alpha1 acid glycoprotein vs. % human serum?

I need to examine the in vitro antiviral activity of a drug in the presence of a series of dilutions of human serum up to 40 percent (e.g., 5 percent, 10 percent, 20 percent, 40 percent). An...

02 February 2021 2,076 1 View

How would you assess protein binding adjusted EC50 for a drug that has a binding rate of over 95%?

I'm in need of a reference or a method to come up with a protocol that allows one to get the protein-adjusted EC50 for an antiviral drug in presence of human serum albumin and acid glycoprotein.

28 January 2021 1,598 1 View

Why is Ribavirin not as widely used as Oseltamivir in treating Influenza?

All literature data I came across showed that Ribavirin had equal if not greater effect in titer reduction, survivability, and body weight loss compared to Oseltamivir. The biggest difference I...

04 December 2020 2,425 2 View

What may cause differences in vascular remodeling drug effect in monocrotaline and sugen/hypoxia induced pulmonary arterial hypertension rat models?

Same drug and dosage was tested in MCT and SuHx PAH rat models but exhibited suppression of vascular remodeling in the MCT model only. What may contribute to this difference in results?

23 September 2020 7,464 0 View

What factors may contribute to the PK differences in rats and mice?

I can fathom the idea of PK being different b/w dogs and rodents, but why would I be seeing a significantly different PK profile for the same drug tested on rats and mice?

11 September 2020 8,910 5 View

What is the rationale behind particle size distribution affecting prolonged drug release with intramuscular injections?

Some drugs appear to be more quickly absorbed by the body with smaller particle size while some undergo better sustained release with larger particles. Why? Is it related to the absorption...

12 August 2020 6,850 5 View