I was planning to dock some isolated compounds with the Estrogen receptor associated with breast cancer and found 3 known receptors viz. 3ERT, 2YLY, 2IOK.
You first need to determine if you are interested in human ER alpha, ER beta, or both. After making this decision, you can look at the structures in the PDB and select one or more structures with the best resolution. Some people use a resolution of 2.5 A or better (smaller is better) for docking studies.
Thank you, sir. Are we using higher resolution to minimize errors and have higher quality diffraction data set and can visualize sidechains and backbones of the protein precisely to present more measurements on the model?