Mohammed Sohel Chowdhury

8 Questions 7 Answers 0 Followers

Questions related from Mohammed Sohel Chowdhury

What starting dose/s of the plant extract maybe given to the mice during evaluation of pharmacological activity and why?

To reach the Minimum effective concentration a specific dose of the drug is given to the human. Similarly, for laboratory animals like swiss albino mice, a specific dose of plant extract may be...

14 May 2017 8,288 7 View

Why the dose of 200mg/kg and 400mg/kg is used for an extract during the neuropharmacological study?

I am performing a neuropharmacological study on mice which involves namely Open field test, Hole cross test (HCT), Thiopental sodium-induced sleeping time test, Elevated plus-maze (EPM test)

11 April 2017 7,753 3 View

Is docking score proper way to measure affinity?

How credible is a docking score to measure the affinity for a particular receptor? Does higher score mean better affinity? It doesn't explain for how long the ligand is bound to the receptor,...

02 April 2017 6,864 8 View

How does docking score corresponds to agonism/antagonism?

If a ligand binds to a receptor giving a docking score, how can you know whether it has an antagonistic/agonistic effect?

18 March 2017 7,060 5 View

How would I know what receptor to use during molecular docking?

I was planning to dock some isolated compounds with the Estrogen receptor associated with breast cancer and found 3 known receptors viz. 3ERT, 2YLY, 2IOK.which receptor should I use and why?

20 February 2017 850 3 View

Can anyone list different In-silico based work for different isolated compounds?

I was wondering what different types of work can be done with pharmacophores pertinent to computer-based modeling linked to lead compound and drug discovery

06 February 2017 4,755 3 View

Is there specific methods/calculation to impregnate various concentration of extract into the filter paper for zone of inhibition?

I was trying to find the zone of inhibition for Lawsonia inermis, so I had to stack pieces of filter paper for different concentration (more no of filter papers stacked- higher concentration)....

22 January 2017 7,659 5 View

How do i identify the layer from chloroform, methanol, water in a separating funnel?

I was performing fractionation for a plant extract, i was perplexed by the answers i found on the internet as "denser solvent is the lower portion" .however, another answered the separation is...

15 January 2017 997 13 View