I want to know how and when aPL was discovered, as well as who are most susceptible in acquiring APS.
Antiphospholipid antibodies were discovered by a British team lead by Graham R.V. Hughes, who is a rheumatologist, in 1983. Prior to its discovery, the research and discovery of the lupus anticoagulant in 1953 by Conley and Hartmann has paved the way to see such autoimmune antibodies and later discovered several conditions such as Systematic Lupus Erythematosus (SLE) and the aforementioned Antiphospholipid Syndrome (APS). Harris, N. E. (2009). History of the Antiphospholipid Syndrome. Scielo.Org.Co. http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0121-81232009000400001
Antiphospholipid Syndrome is an autoimmune disease present mostly in young women. It affects women five times more commonly than men. It is typically diagnosed between the ages of 30 and 40. While up to 40% of patients with SLE will test positive for the anti-phospholipid autoantibodies, only half will develop thrombosis and/or experience miscarriages. American College of Rheumatology Committee on Communications and Marketing. (2021). Antiphospholipid Syndrome. Rheumatology.Org. https://www.rheumatology.org/I-Am-A/Patient-Caregiver/Diseases-Conditions/Antiphospholipid-Syndrome