In many bioinformatic studies, the author calculated each patient's riskScore according to hub genes and then validated its prognostic value in multiple GEO datasets using the median value in TCGA. However, there was no significant statistical difference in Kaplan-Meier survival curve when i used this method. I nearly used every GEO series as i can found in GEO dataset. Besides, some hub genes also missing in GEO datasets in some situation. So how could they achieve this procedure? It did confuse me all the time.
Dear Aimin Jiang
These articles might be an asset, have a look:
1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017186/
2. https://www.frontiersin.org/articles/615834
3. https://www.frontiersin.org/articles/10.3389/fmolb.2021.675198/full
4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7879943/
5. https://www.biorxiv.org/content/10.1101/2021.06.26.450025v1.full
6. https://cancerci.biomedcentral.com/articles/10.1186/s12935-020-01255-2
Kind Regards
Qamar Ul Islam
Article A novel scoring system for gastric cancer risk assessment ba...
- Badges
- Science topic
- Similar topics
- Mathematical Sciences
- Statistics
- Statistical Software
- SPSS