Dear Bably:

An easy way to complex some drug in CDs is to mix together in a water/solvent solution. After that, using evaporation or something like that to recover the complex. Please see this publication to ilustrate:

Article Liposomes incorporating cyclodextrin–drug inclusion complexe...

Thanks Adrián Matencio for your reply. But I have a drug to make complex with Hydroxypropyl beta Cyclodextrin. What I wanted is to tag folic acid onto HPBCD-drug complex

Ok. In that case I would recommend to check any chemical reaction able to tag any functional group of tour vitamin at CDs -OH. Kind regards

Thank you Adrián Matencio . I have found a method but I am not sure whether it will work for cyclodextrin. Have to do the experiment.