what method do you want to use for the synthesis? To control the size or shape of nanomaterials you can add some additives or surfactants during the synthesis. Also, by adjusting experimental conditions you may be able to control the size. For example, in our method - Pulsed Plasma in Liquid, we can play with (pulse) discharge duration, it really affect the size, shorter the duration, the smaller the size.

Zhazgul thanks for your reply i wish to use electrospinning for fabrication of nanofibers.

yes, electrospinning is one of the best possible methods to fabricate nanofibers less than 50 nm , but varying the voltage and other parameters, we can reach the diameter as less than 10nm. also depends on the polymer and the solvent you want to use.

Thanks Ruchika for your kind help

Load your drug on a suitable polymer (biodegradable ones are the best) then use electrospinning at high voltage after dissolving the polymer loaded drug in a suitable solvent (water is not preferred) to make a scaffold of the polymer bearing the drug. Many articles are available in this field. You can use the keywords you have like the name of the drug, the polymer, the solvent together with the word electrospinning to get a unique result.