I am interested in a compound that can enhance memory or protein memory. We don't have access to mice or other animals, so does anybody have any suggestions for cell models or methods that are available for an experiment like this, either in neuro cells or metabolic cells? Thanks.
You could try something like the studies cited in this review. How much potentiation or habituation in neural cell lines relates to memory is certainly debatable though.
FASEB J. 1991 Apr;5(7):2061-7.
Short-term and long-term memory in single cells.
Morimoto BH1, Koshland DE Jr.
Author information
1Department of Molecular and Cell Biology, University of California, Berkeley 94720.
Abstract
Many approaches have been used to study short- and long-term memory. Bacteria detect chemical gradients using a memory obtained by the combination of a fast excitation process and a slow adaptation process. This model system, which has the advantages of extensive genetic and biochemical information, shows no features of long-term memory. To study long-term memory, neural cell line systems have been developed that exhibit two phenomena associated with learning and memory, habituation and potentiation. The expression of these phenomena in clonal cell lines, devoid of synaptic connections, makes it possible to study the biochemical and molecular mechanisms that contribute to short-term and long-term memory.