How to solve Related Compound C(Known Impurity) issue in Pregabalin extended release tablets formulation?

01 November 2022 1 5K Report

I am working with formulation development of Pregabalin Extended Release tablets. But I am facing trouble with a known Impurity. During stability this impurity is increasing rapidly. i have done one to one compatibility study with all the excipients and found that Carbopol 71 G is the culprit. But innovator company is using this particular ingredient. So I cannot omit it. Please guide me how to solve this issue. I don't understand what the innovator company is doing to reduce this impurity.

Sandson tafireyi Eagle

Maybe there are other excipients to compact it, you need to dig a little deeper

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