Hi community,
I have a dataset of individuals of a species (several populations) genotyped at 9 microsatellites.
I would like to ask if (and how) I could simulate that STR data forward in time, so to implement different scenarious (e.g. cut-off of one population, varying migration rates between populations, etc)?
Ideally, the simulated data (forwarded for X years/generations) would be in allele frequencies or even STR data format as well, so that I can compare the initial and the forward-simulated data using standard procedures of population genetics. It seems to me that some programs are able to simulate STR-data forward in time (e.g. R package skeleSim using Rmetasim), yet as initial data they also use simulated data. So I think it should be able to use real STR data instead of the simulated one? But please correct me if I am wrong here.
Your help is appreciated,
Florian
Hello Kuns! In my part of the work a deal with proteins. I have already work with DNA samples and some technics including microsatellites but I am not a specialist.
Hi Ronaldo,
thanks for your answer.
Does this mean you have some experience about forward-simulation? If so, could you please share it with us?
Cheers Florian
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