I recorded sEPSC in striatal medium spiny neurons and saw an increase in the rise time when a GPCR agonist is applied. The agonist is supposed to act on presynaptic neurons to increase their excitability. The increase in rise time probably indicate that the drug is affecting a certain population of presynaptic neurons.
Here is my issue: The mean increase in rise time is very small. If you look at the average values, the increase goes from 2.8ms to 2.9ms, for example. Although it is a significant increase (p
Dear Miao,
It really depends on many factors such as data acquisition rate, how you have measured, precision margins/noise level and how you analyzed your data. Did you include the average of each cell or did you use each individual event? Also how many events per cell? Personally to me, the change of rise time increase from 2.8ms to 2.9ms does not sound convincingly significant or physiologically relevant-it could be just within the measurement error/noise range.
Best wishes,
Refik
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