I am doing catalytic oxidations on a larger scale with mcpba as the oxidant. But, everytime after work up with DCM/Et2O and base (triethylamine or NaHCO3), m-chlorobenzoic acid still remains in the solution. Please help.
Also to mention, the desired product is mainly alcohol.
Riaz A. Khan
At bulk preparation levels, the workup is really tricky with remaining m-CPBA! Both the product and the remaining m-CPBA co-exist in the same phase and separation is not complete. Efforts to remove the m-CPBA ends in loss of product which is substantial at higher quantities. The in-mixture m-CPBA can be removed chromatographically through filtration/ adsorption based techniques in separations as well as pH based separation can also be tried.
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