what solvents are the best to maintain buparvaquone activity in a 5% injectable form? is NMP good without the addition of DMSO?
Check this out: dimethylacetamide, N-methylpyrrolidone, benzyl alcohol, an antioxidant, dimethyl sulfoxide: Indian Journal of Pharmaceutical Education and Research |Vol 54 | Issue 3 | Jul-Sep, 2020
Patent: CN105769760A
Dear Ola Whbe for some general information about the stability of buparvaquone please have a look at the following relevant article:
Exposure to ambient air causes degradation and decreased in vitro potency of buparvaquone and parvaquone
Article Exposure to ambient air causes degradation and decreased in ...
This paper has been posted as public full text on RG and can be freely downloaded as pdf file.
Also please see the following potentially useful reference:
Development and Validation of Stability Indicating Method for Estimation of Buparvaquone by Forced Degradation Studies
http://www.ijper.org/sites/default/files/IndJPhaEdRes_54_3_790.pdf
(see attached pdf file)
In the case of NMP you should perhaps consider possible toxic effects:
Toxicity of N-methyl-2-pyrrolidone (NMP): teratogenic, subchronic, and two-year inhalation studies
Article Toxicity of N-Methyl-2-pyrrolidone (NMP): Teratogenic, Subch...
Good luck with your research! 👍
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