I have a high density product contains 30% Oxytetracycline dihydrate dissolved in pyrrolidone, it is very difficult to filter with vacuum filtration method ( 0.2 or 0.45 micron nylon filter paper) is there any other way for filtration with 0.2 micron filter paper?
Dear Ola Whbe , A syringe filter is an ideal technique to use a 0.2 micron filter.
You an filter using a syringe, either by pressing the plunger gently or letting the fluid filter by gravity (by carefully removing the plunger from the top).
Dear Ola Whbe
I suggest that you try the membranes filteration with 0.2 microne, and it is necessary to choose the membrane material that is not affected by the mentioned materials
Regard
It looks like your filtration is difficult because the high value of the viscosity of the fluid (not quite density). If you can increase temperature the viscosity will decrease.
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