For example, during the process of CNS lead optimization, compounds will be measured for potency, selectivity, CYP inhibition profile, solubility, BBB permeability, toxicity, etc. How are the compounds ranked based on these properties? If we set cutoff values for these properties, does NCE that meets all criteria gets to move into in vivo evaluation or it's OK for compounds that only meet several criteria like potency, BBB permeability etc?

More Chenxiao Tang's questions See All
Similar questions and discussions