Chenxiao Tang

5 Questions 1 Answers 0 Followers

Questions related from Chenxiao Tang

Is it meaningful to study dose-response relationship in animal?

If I would like to study the effect of a small molecule compound in animal, say rat. Do I need to conduct a dose-response study with 4 to 5 different doses in rats? Usually people find the maximum...

14 May 2019 9,413 3 View

How long/short of a half-life is too long/short?

for small molecules that aims to penetrate BBB. how long of a half life is appropriate? Is there a too long or too short half life? how long is too long or too short?

19 March 2019 5,473 2 View

How to measure ROS and intracellular calcium in vivo in brain?

I would like to measure neuronal intracellular calcium and brain ROS production in rats. I have seen several in vivo calcium imaging and ROS imaging papers, I haven't come across papers that talk...

06 March 2019 2,145 0 View

Does Ki of an inhibitor change based on different substrates of an enzyme?

For example, will Ki of cimetidine change based on different CYP3A4 substrate?

19 February 2019 9,176 10 View

How to rank new chemical entities based on their chemical properties and PK properties?

For example, during the process of CNS lead optimization, compounds will be measured for potency, selectivity, CYP inhibition profile, solubility, BBB permeability, toxicity, etc. How are the...

01 January 1970 5,384 2 View