I have used Swissmodel, MODELLER, Phyre, Robetta and I-TASSER for modelling my protein, but in the modelled structure, amino acid is not observed at a specific position to which I want to induce a mutation. That amino acid is present in sequence, but absent in modelled structure of all these mentioned tools. Is there any other way of modelling a structure that covers maximum sequence coverage so that I find that residue at its intended position in modelled structure?
Dear Rucha wadapurkar,
I suggest you to see links and attached file on topic
.
https://proteopedia.org/wiki/index.php/Practical_Guide_to_Homology_Modeling
https://arxiv.org/ftp/arxiv/papers/1510/1510.05682.pdf
Article Can Predicted Protein 3D-Structures Provide Reliable Insight...
Article Probabilistic multi-template protein homology modeling
Best regards
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