Sever increase in serum iron for example in iron sucrose parenteral consumption for hemodialysis patients occasionally create iron toxicity. In this situation TIBC has false increase in colorimetric method.
I hope that following papers are useful, plz check out.
Have a nice day
Article Usefulness of the Total Iron Binding Capacity in the Evaluat...
Article Total Iron-Binding Capacity–Estimated Transferrin Correlates...
Article Assessment of acute iron poisoning by laboratory and clinica...
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