I have two groups of mice representing WT and knockouts. Each mice group (WT and KO) will be allocated to 4 experimental categories. I need to allocate these available mice into these experimental categories, with no intra-category and inter-category significant differences in their age and weight. Is there any accepted way to group these mice by matching their age and weight?
Dear Udeshi, knocking out of that gene had any effect on their feeding behavior or body weight? You must match their age, and you can do that easily if you know their date of birth. But their body weights (mass) usually depend on several factors. For example the size of the litter (bigger litter-less milk from their mother), any complications during birth or they cannot access the same amount of food in their home cage due to the ranking position (bigger mice eat more food or cannot let others eat). I think you must allocate them by genotype and age, but not by weight. Only thing you may consider is exluding outliners from the experiment from the beginning (the biggest and smallest mice).
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