I've been preparing a film of hyaluronic acid intended to administer in the skin. My main objective is to prepare a film that can dissolve really quickly in the skin surface. Despite Hyaluronic acid itself being a high-molecular-weight polysaccharide, I also added Polyvinyl alcohol as a film forming agent. Additionally, I introduced sodium starch glycolate as super-disintegrants as well as gelatin to make the film melt away rapidly. However, I haven't got the success as much as I would have liked. What would be the best strategies for rendering the film dissolvable in normal skin condition? Thank you.
@ Berno I. Pettersson, Jr. Can you please let me know the transdermal system that you have used? Thank you.
Can you tell me the intended use of your films? e.g. wound healing, infection or else
Use low molecular hyaluronic acid....and add crospovidone...adjust the pH of your formulation in such a way that it should be dissolved at skin pH (5.2-5.5).
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