First I synthesise the Plga nanoparticles with loading of Hydrophobic drug in it. Then I use chitosan to coat the hydrophobic drug loaded plga nanoparticles. while the coating the chitosan over time, I loaded the hydrophilic drug. Then I lyopilize the samples. Now I want to check the drug loading % of both hydrophobic and hydrophilic drugs. What solvent can I use to dissolve the chitosan and plga to find drug loading % of both hydrophobic and hydrophilic drug.