The killing capacity of some antibiotics is time-dependent, whereas it is concentration-dependent for others. For time-dependent antibiotics, the most important factor is the time that a therapeutic dose is spent above the MIC, whereas for concentration-dependent antibiotics, it is the ratio of the peak serum concentration to the MIC. Time dependent antibiotics include beta-lactams, carbapenemes, doxiciclin, tygeciclin, clindamicin, glycopeptides and linezolid.
Have you any experience on continuous infusions of antibiotics (apart from vanco) and practical suggestions (i.e., dosages, dilutions and speed of infusion) especially for beta-lactams and carbapenemes?
Hi Marco.We have experience on use of pip-tazo 4,5 g e.v. in three hours four-times in a day (obviously if GFR > 60 ml/min), but also in continous infusion on 24 hours. The second way of administration is maybe more easy to use by nurses. We use vancocin always on continous infusion
For Time dependent antibiotic is best practice by continuous infusion, BUt pay attention the half life of the antibiotic (of both potency and clearance), so you can determine the length of continuous infeusion
in my hospital is still implement the frequent dose rather than continuous infusion
rgds
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