My compound is fused thiazolo[2,3-b]pyrimidinone derivatives, they can easily soluble in Chloroform at RT. I tried in chloroform, methanol for the single crystal. But I am not getting the crystal. Please give your valuable suggestions.
I hope you get petroleum ether of different boiling
points. Try the solvent with maximum solubility or ethylene glycol .
Hope you get good crystals.
all the best for your trials. - GR
Hi
Use suitable solvent, or mixed solvents
Put the vial of sample at room temperature
Do not check the vial
good luck
Hi
First take small size (5 mL) vial, add your compound (your sample+pure chloroform) and another one vial (10 mL) filled hexane or petrolium ether .small vial (sample+chloroform) insert 10 Ml vial and kept for fridge. good luck
Diffusion of diethyl ether or similar solvents into a small vial with the dissolved compound often works well. You can slow down the diffusion process by capping the small vial and making a few holes in the cap. Very slow evaporation of the solvent could also work just fine. The important thing is (as said above), don’t disturb the process, just wait a week or too before you check and don't move it until you see the crystals.
First, send me please a solubility curve of your crystal in one (or more) solvent. Then, I' ll find a suitable way to obtain a good crystal
All the best
Dino
Generally, there are two straightforward and cost effective methods for growing single crystals: inverse temperature crystallization (ITC) and anti-solvent method.
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