Why am I not able to use all VEP programs for the in silico analysis of avpr1b SNP's?

01 March 2021 1 5K Report

Good day researchers

I am busy analysing the predicted effects of certain SNP's in AVPR1b. When using the VEP prediction programs (SIFT, Polyphen, FATHMM, LRT, Provean, Mutation Assessor, and Mutation Tester) only SIFT, Polyphen, FATHMM and Provean will give me results the other three programs do not. I am not sure why this and would like to know if anyone has some insight in this matter?

Kind regards Michelle

Mohaned Abd Alrahman

لا أعلم

Badges
Science topic

Similar topics
Econ
Business Economics
Business

More Michelle Steven's questions See All

Should we reduce the standard unit of length to 0.31951540592 meter ?

The reasoning behind this question is to align the ratios of the proton potential in energy per charge to the speed of light in distance per time. As these two dimensions appear to be related,...

27 February 2021 947 7 View

Can I use a likert survey for criterion sampling in a qualitative study or would that make it mixed methods?

I am doing a phenomenographic study on the reading experiences of avid v. Neutral v. Non-Readers. If I use a likert survey to criterion sample for participants, does that make it a mixed method...

09 February 2021 8,594 3 View

When is it optimal to choose an OFAT (One factor at a time) design over DOE (design of experiment)?

As a current undergraduate student majoring in Microbiology who is still learning DOE (Design of experiment) on my own, I have heard and read that an OFAT design is considered the most inefficient...

29 January 2021 8,256 3 View

Lighting for open field test behavior assay?

I am currently setting up our lab's behavioral space to run the open field test in rats, and I am trying to figure out how to set up lighting to evenly illuminate the open field chamber (a 90 cm x...

26 January 2021 1,399 3 View

What metal thin film houses also do annealing?

Could anyone provide names of metal thin film deposition vendors that also do high temperature annealing, in the range of 300-500 C?

27 December 2020 6,137 3 View

Why is my blot transfer bad now?

I had been having beautiful blot transfers, but in the last few days I have ran into issues where there is high background staining and poor band resolution. The background staining is very...

23 December 2020 670 3 View

Vacuum freeze drying protocol in human skeletal muscle tissue methods, anyone?

I will be freeze-drying small skeletal muscle samples (~60mg) per sample using a Virtis SP Scientific Benchtop Pro Freeze Dryer. I've had difficulty findings a reference protocol to determine the...

21 November 2020 1,423 1 View

Does anyone freeze samples in GeneJET RNA extraction kit lysis buffer?

For the GeneJET RNA purification kit from Thermo Scientific, does anyone know if you can lyse your sample (suspension cells in my case) in the lysis buffer from the kit and then keep the sample at...

18 October 2020 4,993 3 View

How/where to provide a dataset?

If someone has collected a large useful dataset that could be useful to social science research, gender research, a specific industry sector in business, and possibly business students or those...

05 October 2020 9,236 6 View

Looking for good/reliable betaine assay kits. Does anyone have experience with such a thing?

I am looking to quantify both human serum and skeletal muscle homogenate betaine concentrations via ELISA or colorimetric assay kits. Has anyone had a good experience with any products...

24 September 2020 4,550 3 View

How to repeat an operation on an atom selection for multiple times in PyMol?

Hi, I am trying to construct a multi-layer fibril structure from a single layer in PyMol by translating the layer along the fibril axis. For now, I am able to use the Translate command in PyMol...

02 March 2021 4,569 4 View

What does Servant Leadership mean today and in the future? What are the advantages and disadvantages?

In current time of many changes in business and world of work, a lot is said and reported about the importance, skills and benefits of leadership. Are soft skills becoming more and more important?...

02 March 2021 8,149 3 View

What are possible instrumental variables for business dynamics (firm entry/exit)?

Dear All, For my paper, I use business dynamics (firm entry/exit rates) as an independent variable in the econometric part. Due to endogeneity I follow a 2SLS approach, for which I need a...

28 February 2021 5,322 3 View

What is the difference between genotype and haplotype data in the ped format?

Hi everybody In the ped format for genotype, alleles of any SNP are represented by two columns (one for each allele, separated by a space). Is a column sufficient for the haplotype to...

27 February 2021 1,965 1 View

What are the important topics in the field of Artificial Intelligence in Business world?

Dear All, I am doing my MS in Electronic Businesses. And I am interested in the AI field and its applications for businesses, its benefits, impacts, etc. What kind of scientific research dominate...

26 February 2021 8,816 6 View

What software programs can directly simulate Additive Manufacturing Directed Energy Deposition (DED)?

I understand there are a lot of software programs that can simulate DED by going through specific modeling, simulation, and commands. For me, that was time consuming and results were not accurate....

24 February 2021 4,428 3 View

Any Differences in COVID-19 vaccines?

Are there any differences (outside of the clinical trials that led to their EUA) observed in the rate of infection among those who have received the Pfizer vs Moderna vaccine since the mass...

22 February 2021 9,727 6 View

How can misfit between business requirents and ERP system business process be reduced?

One main reason for failure of most ERP implementations is the misfit between business requirents and ERP system business process be reduced. How can the misfit between business requirents and ERP...

22 February 2021 5,709 5 View

Why is ethics significant in business and how should one control unethical behavior ?

1. The significance of ethics to business and how to control bad behavior.

21 February 2021 882 14 View

FDC and FRC cell populations in mouse spleen?

I was trying to isolate fibroblastic reticular cells (FRC) and follicular dendritic cells from mice spleen, but kept getting poor yield. I found from literature that the frequency of FDC is around...

17 February 2021 3,506 4 View