Hi!
We are using microfluidics to fabricate gel beads. Though they have a central mean, the distribution presents a quite discrete distribution. However for our application we need to strictly rid off bead >60um.
This is not a usual size in cell strainer and I cannot find 60um cell strainer in China. Instead, I ordered some stainless steel net. The problem is that the steel net is quite elastic. Even with pole size to 55±2um, there are still seldom 60-61um beads remain.
Is there any other method to rid off the >60 bead?
Dear Zonghan Gan , probably the best and simplest way would be to use a sieve with a light smallest than 60nm as you did, may be you can use one with say 50nm to be sure all the particles bigger than 60nm are removed, may be you must sacrifice some particles that still could be useful for your experiment, but at least you will sure that avoid clogss of your microfluidics by oversize of your particles.
Hope it helps.
Sieving, extrusion (instrumental) seems to be your choice as Dr. Gomez also suggested.
There are different possibilities:
If the particle's density differ from the liquid: centrifugation may do it.
Dielectric materials may get attracted and separated by electrical fields according the their surface area. I don't know if this matches hydrogel-particles.
Otherwise shear flow can also separate according to particle size.
Best regards, Claus / Biophysical Tools GmbH
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