Now days trace metal assay ,such as zinc,copper ,manganese and others have effect on
cornory disease (CAD) is a leading cause of morbidity and mortality in developed countries and is emerging as an epidemic in developing countries (1). Traditional risk factors such as serum cholesterol, blood pressure and smoking account for not more than 50% of CAD mortality (2). There is strong evidence that oxidative free radicals have a role in the development of degenerative diseases including CAD (3). Oxidative free radicals increase the peroxidation of low density lipoprotein (LDL) thereby increasing its uptake by macrophages with increased foam cell formation and atherosclerosis, though other mechanisms may exist (4). Each antioxidant has different and important mechanisms of action since oxidative damage can be caused by lipid- or water-soluble molecules. Lipid-soluble antioxidants are likely to be very important in preventing the peroxidation of LDL and this action could be paramount in the prevention of atherosclerosis. As lypophilic molecules, vitamin E and beta-carotene are incorporated into the LDL particle. Vitamin E plays an essential protective role against free radical damage (5). Previous experimental and epidemiologic evidence suggested that some antioxidant vitamins appear to be important in reducing the risk of CAD (6).
Studies on the roles of trace elements in health and disease over the past 50 years have led to a good understanding of their mode of action and why they are essential to life (7). Some studies have assessed the association between iron status and CAD risk but the results have been inconsistent (8,9).so how to find correlation to health?
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