Hi there,
I had some trouble finding suitable concentrations for the synergism of two drugs. My experimental design is as follows, and the calculation is used CompuSyn:
Data for Drug: A [uM]
Dose Effect
50.0 0.0792
100.0 0.3117
250.0 0.3938
500.0 0.5575
1000.0 0.9502
Data for Drug: B [uM]
Dose Effect
50.0 0.017
150.0 0.1656
300.0 0.3788
500.0 0.6461
700.0 0.7935
CI Data for Non-Constant Combo: A+B
Dose A Dose B Effect CI
10.0 500.0 0.6129 1.12282
25.0 500.0 0.6742 1.02014
50.0 500.0 0.6381 1.17713
100.0 500.0 0.6313 1.33936
250.0 500.0 0.6847 1.55157
I would like to find suitable concentrations for A+B (CI
If you are working on Chemotherapeutic agents, first determine the Minimum Inhibitory Concentration of each of the substances. Then combine the substances at 25% of the MIC of each substance. If you don't obtain expected effect at this point, try additive effect by combining 50% of the MIC of each drug.
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