miRNAs are epigentic regulators and altered expression is reported in cancer. How to find out mutations in miRNA genes and their relevance in cancer? or are the mutaions in miRNA genes or its altered expression relevant in cancer?
Cell-to-cell communications require miRNA which exist in exosomes. The malignant transformation of normal cells undergo apoptosis/ senescence through cellular competition or evasion from the exclusion from the epithelial tissue. It has recently been shown that tumor-derived exosomes contain mutant driver genes such as KRAS in pancreatic cancer cells. Tumor-derived exosomes contain multiple kinds of miRNA, mRNA, and proteins, and further contain glypican1 exclusively.
Article Glypican-1 identifies cancer exosomes and detects early panc...
Thank you Charitha. This is an interesting question.
I do not think their altered expression would cause cancer, but contribute to cancer potentiation, according to the evidences in colitis-associated colorectal cancer models that I have found.
It is hard to say whether their mutations were really relevant, but their regulators. However, as fas as they are very important metabolic modulators, it is very interesting to find out ways to detect promptly their alterations in any kind of cancer.
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