Can any body suggest the transwell system for dissolution behavior of inhaled particles?

I am looking for a proper method of dissolution for my micronized particles if any body can suggest a protocol.

08 September 2016 8,186 2 View

Can anyone help us with the development of an easy protocol for semi-solid transdermal drug formulations from various plant extracts?

We want to extract active medicinal constituents from locally available plants and to formulate them into semi slid transdermal formulations like, emulgel, ointments etc.

07 August 2015 9,265 8 View

What is the Polymer of choice now a days for SR Tablets?

07 August 2014 2,044 4 View

How could the solubility enhancement efficiency of any compound be evaluated?

I want to enhance the solubility of few lipid compounds.

31 December 2012 2,067 1 View

Can anybody share his/her experience for the solubility enhancement of Clofazimine which is a lipid soluble compound?

I want to determine the solubility of Clofazimine and then to try the enhancement of its solubility using various lipid solvents, lipid-water mixtures and buffers.

11 December 2012 8,101 7 View

What is the main difference between research proposal and synopses?

I saw an ad asking for both for an award of PhD scholarships.

10 November 2012 3,971 26 View

What is an appropriate number of authors in a research publication?

Some times 8 or more people contribute in a projact.

09 October 2012 1,366 8 View

Does Napabucasin soluble in dichloromethane and in ethanol?

I need to prepare a solution of Napabucasin (inhibitor of cancer cell stemness) in dichloromethane. The drug is expensive, so maybe somebody already tried to do it. If it is soluble, what is the...

02 March 2021 9,945 3 View

What is the state of the drug inside solid lipid nanoparticles (SLNs)?

I am a little confuse with the mechanism of solid lipid nanoparticles (SLNs). The main point of encapsulating drugs into SLNs is because some drugs have low solubility in water. Therefore, SLNs...

01 March 2021 3,703 3 View

Precipitate after adding laemmli buffer to protein solution containing Potassium Acetate?

Hi, I am running a size exclusion chromatography experiment with a buffer containing Potassium Acetate as a salt. I analyse these fractions through SDS-PAGE. After boiling my SEC fractions in...

01 March 2021 2,622 3 View

Do you kow of any database containing data on retention time, log P and polarizability for a large number of molecules?

Hi, I am a chemistry undergraduate doing my dissertation project on HPLC. In my project, I need to predict the HPLC retention time of 20 aromatic molecules, the calibration set. To do this I will...

24 February 2021 2,602 1 View

Can two EC50 values with different hill slopes be compared?

Hello, I fit a classical dose response curve Y=Bottom + (Top-Bottom)/(1+10^((LogEC-X)*HillSlope)) to my data (not related to inhibitors etc). The model I use is purely qualitative but it fits...

23 February 2021 8,155 5 View

Model Volume fraction and magnetic field applications of nanofluids in ANSYS?

Hi I am working recently on a project where I have to study how the thermal properties or heat transfer enhancement of nanofluids as the volume fraction changes, or if a magnetic field is applied...

22 February 2021 961 2 View

How to seperate PEG-4000 from aqueuse phase ?

Hello everyone , Please tell me if It possible to seperat POlyethelyn glycol -4000 from an aqueuse media by other ways rather heating . I have tried salting out by electrolyte solution to...

22 February 2021 7,285 5 View

Will SARS-CoV-2 Spike be broken into S1 and S2 by denaturing conditions?

Hello, I am performing a western blot of my SARS-CoV-2 Spike-pseudotyped lentiviral particles. I denature my virus by adding concentrated virus to 2X Laemmli buffer at 1:1, then boiling for...

17 February 2021 4,844 4 View

How to analyse monosaccharide compositions from soluble fiber?

I have tried to hydrolyze the sample using 2 M TFA at 100C for 24, 48 h and 120C for 2 h. From these conditions, the HPLC results showed that peaks were not separated into monosaccharide. I found...

17 February 2021 5,230 1 View

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Hello. I ask for help - I need to get lithium tetraborate (soluble salt) from lithium carbonate and boric acid. In literature, everything seems to be simple - mix, ignite and - it's done. But it...

16 February 2021 9,523 2 View