Gilbert's syndrome and Crigler-Najjar syndrome have similar clinical manifestations. Do characteristic differences exist in the ultrastructure of the liver?
If you're interested in the differences in the molecular biology:
Gilbert's syndrome involves a mutation in the promoter sequence for UGT, which leads to decreased production of the functional enzyme. Crigler-Najjar involves genetic mutations within the enzyme that results in either a completely dysfunctional protein (C-N I) or a protein with minimal activity (C-N II).Clinical manifestation is not the same as patients with Gilbert can lead normal life whereas those with Criglar Najjar usually die earlier(neonatal period) however both will give rise to unconjugated hype bilirubinemia
In both Gilbert's and Crigler-Najjar there is an impairment of UDP glucuronosyl transferase. In CN levels are extremely low (undetectable in type 1 and
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