How to determine the way to inject toxic material into rats subcutaneously or intravenously ?? Is there a difference between these methods ??

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Luiz Querino Caldas

Of course there is. Each via will certainly give you a distinct way of body absorption. The kinetics differs quite substantially, the late absorption being SC. There are many pharmacokinetic texts showing that , for instance, bioequivalence procedures would help you a lot. Also , you can see these differences by determining the LD50 or the NOAEL of a toxic compound in both ways.

Qaswaa Yousif Jameel

Luiz Querino Caldas I am very grateful to you

Varun Ahuja

There are two initial deciding factors: 1) formulation prepared, 2) exposures (determining efficacy).

Attaching two relevant papers.