In the context of oxidative stress, the levels of oxidative enzymes can vary depending on the phase and severity of the stress, as well as the adaptive response of the organism or cells involved.
Initially, upon the onset of oxidative stress, there is often an upregulation of antioxidant enzymes as part of the cell’s defensive response. This includes enzymes such as superoxide dismutase (SOD), catalase, and glutathione peroxidase. Their levels may rise in an attempt to neutralize the increased production of reactive oxygen species (ROS) and to restore redox homeostasis.
However, if the oxidative stress is sustained or intense, it can lead to a situation where the antioxidant defenses are overwhelmed. In chronic or severe cases, the levels of these enzymes may not be maintained, and their activity could eventually decrease due to the damage inflicted by persistent ROS, leading to the observed low levels of oxidative enzymes.
Furthermore, the expression of these enzymes can also be modulated by numerous factors, including genetic regulation, the presence of cofactors, and the availability of substrates. Therefore, assessing the levels of oxidative enzymes provides a snapshot of the dynamic balance between pro-oxidant and antioxidant forces at a given time.