How to design an aptamer for peptide/protein in silico?

More Nikhil Maroli's questions See All

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Nikhil Maroli

Hi Shirley Dong ,

I am looking for a computational tool or mechanism for developing RNA Aptamers in silico. Later, i can synthesis it and test it in vivo.

Michael G. Weller

I never heard from such an in-silico approach. I also assume that the computational and design effort would be much higher than the proven SELEX technology. The cheapest way to obtain a binder to a protein/peptide may be the production of a polyclonal antibody.

Papori Buragohain

Hi Nikhil,

If your protein/peptide have any RNA binding information than that can be utilised in designing ur RNA Aptamers in sillico. You may refer the following paper:

https://www.nature.com/articles/srep21285