If you have already calculated the OEL, then it can be used to define the OEB category which is used to define the containment/safety procedures applicable. This is the normal procedure.

Thanks for the response Dr.Varun,

Actually I have used NOAEL obtained from 6 months repeated dose toxicity study, to derive OEL. Now how best can I can categorise on OEB using OEL value I have R8 now. Please share if you any references on the same

Regards

G.L.Vishwanath

Hi, 6 months study is a good data to derive OEL, rest depends on the choice of your uncertainty/safety factors. You can check TWA data available in public domain for your compound (this is actually OEL, and is available for most of the compounds..mostly in safety data sheets or MSDS. If it is not available for any particular compound, then you can check TWA value for the analogues or compounds of similar class).

There is lot of literature available (I have attached some), which mentions the control banding (1-4 or 1-5) on the basis of OEL. The safety measures can be decided on the basis of banding where the OEL falls, mean that whether the compound can be handled in open or under isolation or use of selected PPEs etc.

Thank you very much Dr. Varun, for the detailed response and references..very much useful..

Regards

Vishwanath