I am running a multicentre study on portal vein obstruction after pediatric liver transplantation in which numerous data will be collected from different centres.
But, honestly, I think that the data will be too heterogeneous because the way to diagnose a portal vein obstruction (stenosis and/or thrombosis after LT in children; and the therapeutic approach are very different between centers.
Any ideas how to deal with such? regarding future ata collection/analysis?can we overcome this by any means?d
Thanks,bader.
Dear @ Bader Alfares
This is a very common problem. In this kind of situation frailty model approach may be considered over competing methods. The following article might help you. Best wishes.
The analysis of multicentre clinical trials when there is heterogeneity between centres. Markus Neuhäuser & Roswitha Senske. Published online: 14 Oct 2009, Jl of Statistical Computation and Simulation 2009;79:1381-87
This is a prevalent problem—the analysis of multicentre clinical trials when there is heterogeneity between centers.
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