I am currently resarching the impact of chronic periodontal inflammation on oral cancer. I found many researchers are using P.gingivalis to infect the oral cancer cells. The technician of my lab doesn't allow students to culture and do any bacteria-related experiments in our lab.
My question is: Is there any other choice that I can use for replacing the P.gingivalis and creating a chronic inflammatory environment for oral cancer cell lines? I know Lipopolysaccharide (LPS) is possible, any other choice? Such like a specific combination of several cytokines and chemokines?
Expecting the answer, and thank you very much.
Experts have long suspected inflammation may play some role in cancer’s development. In 1863, German scientist and physician Rudolf Virchow was the first to make the connection, observing that cancer often develops at sites of chronic inflammation. But researchers have only recently pinpointed chronic inflammation as a primary risk factor for cancer and other serious health conditions. Among the reasons it’s taken science so long to confirm the relationship: Chronic inflammation causes few, if any, outward symptoms. And inflammation by itself is a sign the body is doing its job.
The concept of inflammation is sometimes tricky to grasp because it may seem contradictory. On one hand, inflammation is a healthy process, essential to the body’s ability to heal itself. When you have an infection or injury, the immune system releases white blood cells and chemicals to fight off the infection or repair damaged tissue. But when inflammation persists, or when the immune system triggers an inflammatory response when you don’t have an infection or injury—like that caused by arthritis and other autoimmune diseases—it may damage healthy tissues. “Chronic inflammation is sometimes called 'smoldering inflammation' because it's inflammation that never really resolves. It's the opposite of 'good' inflammation, which your body uses to get rid of bacteria and viruses, and then, once it achieves its goal, resolves," says Eugene Ahn, MD, Medical Director of Clinical Research and Hematologist/Oncologist at our Chicago hospital.
Today, researchers have a fairly broad understanding of inflammation’s split personality. They’ve learned that sometimes, chronic inflammation is caused by factors outside of our control, such as inherited gene mutations that raise the risk of chronic inflammation. But it also may result from lifestyle choices you may be able to change. That’s important because so-called lifestyle-dependent inflammation is on the rise. “The connection between inflammation and cancer has been apparent for a long time, but it may be that it’s now coming into sharper focus because of the increase in lifestyle-dependent inflammation we’re seeing,” Dr. Ahn says.
Experts have long suspected inflammation may play some role in cancer’s development. In 1863, German scientist and physician Rudolf Virchow was the first to make the connection, observing that cancer often develops at sites of chronic inflammation. But researchers have only recently pinpointed chronic inflammation as a primary risk factor for cancer and other serious health conditions. Among the reasons it’s taken science so long to confirm the relationship: Chronic inflammation causes few, if any, outward symptoms. And inflammation by itself is a sign the body is doing its job.
The concept of inflammation is sometimes tricky to grasp because it may seem contradictory. On one hand, inflammation is a healthy process, essential to the body’s ability to heal itself. When you have an infection or injury, the immune system releases white blood cells and chemicals to fight off the infection or repair damaged tissue. But when inflammation persists, or when the immune system triggers an inflammatory response when you don’t have an infection or injury—like that caused by arthritis and other autoimmune diseases—it may damage healthy tissues. “Chronic inflammation is sometimes called 'smoldering inflammation' because it's inflammation that never really resolves. It's the opposite of 'good' inflammation, which your body uses to get rid of bacteria and viruses, and then, once it achieves its goal, resolves," says Eugene Ahn, MD, Medical Director of Clinical Research and Hematologist/Oncologist at our Chicago hospital.
Today, researchers have a fairly broad understanding of inflammation’s split personality. They’ve learned that sometimes, chronic inflammation is caused by factors outside of our control, such as inherited gene mutations that raise the risk of chronic inflammation. But it also may result from lifestyle choices you may be able to change. That’s important because so-called lifestyle-dependent inflammation is on the rise. “The connection between inflammation and cancer has been apparent for a long time, but it may be that it’s now coming into sharper focus because of the increase in lifestyle-dependent inflammation we’re seeing,” Dr. Ahn says.
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