Hi all,
I am presently working on L asparaginase enzyme. I want to express IC 50 concentration in IU. I have IC 50 values in micro grams/ml. Kindly help me out in converting micrograms into IU.
Hello Nuzhath Fatima
There are online tools to convert between mg and IU:
https://mypharmatools.com/othertools/iu
https://www.etoolsage.com/converter/IU_Converter.asp
International units are used to measure the masses of medical substances. One international unit of a certain substance always corresponds to a certain mass of that pure substance. The mass is given in milligrams or micrograms, 1 microgram is 1/1000 milligram and 1 milligram is 1/1000 gram.They are a non-standard units of quantification. Commonly employed to express vitamin amounts, vaccines, hormones and formulations like insulin. The volume or mass that stands for a IU depends on the concentration of potency of the substance, so you cant easy calculate. In your case, I want to believe that you are trying to confuse enzyme units U (mg or mcg or ng/min) with the IU. Please confirm.
- The IU (µmol substrate turned over per min) is an outdated unit of enzymatic activity, please use katal (kat = mol/s) instead. 1 IU = 16.7 nkat.
- An IC50 is the concentration of an inhibitor that causes 50% loss of activity (especially in the case of sigmoidal binding curves, for hyperbolic curves Ki should be used). Its unit is mass per volume (e.g., mg/ml) or particles per volume (e.g., mM), but not IU.
Thank you all for the valuable answers and I really appreciate them . Regards Nuzhath
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