how to calculate sample size for initiating a study after knowing minor allele frequency and odds ratio, for a gene in case control study.
In most of the research articles authors will give odds ratio and genotype frequencies, in few articles they wont give odds ratio at all, I have selected few studies and calculated minor allele frequencies for that
for example : Haptoglobin gene
GF MAF controls
Hp 1-1 0.408 985
Hp 1-2 0.75
Hp 2-2 0.59
Hp 1-1 0.35 1079
Hp 1-2 0.64
Hp 2-2 0.64
sample size for this study is
recessive model 471
log additive model 217
dominant model 814
my query is does my calculation is correct or not I have done it with quantos software
which model should I choose recessive or dominant or additive
additive is showing less sample size should I prefer it for initiating a study