I need to make an esterification between 5,5,6,6,6-Pentafluorohexan-1-ol and any simple primary carboxylic acid.(coupling agent such as EDCI/DMAP, HOBt or activation by making an acyl chloride) It seems that this perfluorinated molecule has a particular reactivity because of the fluorinated moiety, even if I tried with a florous solvent at reflux (TrifluoroToluene)
Does anyone has already work with this molecule or any similar compound (such as 6-Iodo-1,1,2,2,2-Pentafluorohexane) ?