Hi, I'm trying to evaluate a paper that looks into IL-1, MMP3 and atherosclerotic plaque stability and would really appreciate advice if anyone has read this paper or knows about the subject ; "Genetic inactivation of IL-1 signaling enhances atherosclerotic plaque instability and reduces outward vessel remodeling in advanced atherosclerosis in mice"- Journal of Clinical Investigation.

1. Are the brachiocephalic artery and aortic root the most representative vessels to look at when studying the role of proinflammatory cytokines on plaque stability?

2. Does it provide enough evidence to suggest clinical therapies that promote IL-1 should be used and how representative is the mouse model?

Also, other opinions on this paper are also greatly welcomed.

Thank you.