Dear Balavigneswaran,

A mixture of DMSO and buffer pH 7.4 will be a good choice.

Rafik

Dear Prof. Rafik Karaman,

Thank you so much for your suggestion. But, If the Polymeric nanofibers we fabricate itself is of soluble in  DMSO:Buffer (0.5:10) or any other ratio what would be the other system to study? Since DMSO is highly polar solvent

Dear Balavigneswaran,

For biological studies  DMSO, alcohol and dioxane can be mixed with your buffer. In your case, may be alcohol or Dioxane which are less polar solvents than DMSO can play the desired role.

Good luck,

Rafik

Dear Balavigneswaran,

have you tried adding surfactant to the buffer?

Dear Prof. Rafik,

Thank u for suggesting alcohol. If we use 3:7 / 5:5 Alcohol:buffer is there any problem apart from the evaporation of alcohol or pH change due to the evaporation of alcohol?

Dear Fitria,

u meant to say adding tween or anyother surfactant where the drug soluble? I have not tried any such thing. will that work? wont it cause any problem in the release kinetics profile?