How much time should we use the rotary vacuum evaporator for our ethanol extract?

The time required to process 300 mL of ethanol extract using a rotary vacuum evaporator depends on several factors, including:

Vacuum Level: The lower the pressure, the faster ethanol will evaporate.

Bath Temperature: Since you're maintaining the temperature below 40°C, it aligns with preserving thermolabile compounds.

Rotation Speed: Faster rotation speeds increase the surface area for evaporation.

Cooling Efficiency: The efficiency of the condenser impacts the rate of ethanol recovery.

Initial Ethanol Concentration: The more diluted your extract, the longer it may take.

General Guidelines:

Ethanol evaporates efficiently under vacuum at around 35°C–40°C. Assuming you are working under moderate vacuum (e.g., ~100 mbar):

Time Estimate: For 300 mL of extract, it typically takes 30–60 minutes, depending on the above factors.
If ethanol recovery slows significantly after initial evaporation, you may need to increase vacuum strength slightly.

Tips for Optimization:

Monitor the evaporation progress visually and by checking the condensate.

If the evaporation slows down near the end, check for any issues with vacuum integrity.

Avoid over-evaporation to prevent burning or concentrating beyond your target.

If you provide additional details like the vacuum pressure or the type of extract (e.g., aqueous or oily phase), I can refine the estimate further.

James Henderson Mitchell

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Marlyn Sabocojan

Thank you for answering my question @James Henderson Mitchell. However, i would like to know if what vacuum pressure is appropriate for our extract?

Carlton Hoyt

The recommended vapor temperature for ethanol extraction is 25–30°C. Boiling ethanol at 30°C requires a pressure of 123 mbar, and boiling at 25°C requires a pressure of 95 mbar.

This article contains a lot of information about removing ethanol in cannabinoid concentration applications, but it is broadly applicable to many applications where ethanol is a solvent: https://labsup.net/blogs/blog/ethanol-removal-in-cannabis-applications

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