Caplan's mesenchymal stem cells express CD105, CD123, and CD166 cells surface markers, conform to Hayflick's limit, and differentiates into cartilage, fat, and bone. The mesodermal stem cells we work with express CD90 and CD13 cell surface markers, expresses telomerase, has essentially unlimited proliferation potential, and can differentiate into skeletal muscle, smooth muscle, cardiac muscle, unilocular white fat, multilocular brown fat, hyaline cartilage, articular cartilage, growth plate cartilage, elastic cartilage, fibrocartilage, compact bone, cancellous bone, tendon, ligament, dermis, scar tissue, dermis, loose fibrous CT, dense fibrous CT, organ capsules, organ trabeculae, endothelial cells (large arteries, muscular arteries, small arteries, arterioles, fenestrated capillaries, non-fenestrated capillaries, venuoles, small veins, medium veins, large veins, [lymphoid vessels]), hematopoietic cells (multiple), spleen, and kidney.
Mesenchymal stem cells have the ability to differentiate into osteogenic, chondrogenic, and adipogenic lines. MSCs are classified as adult stem cells as they have the ability to differentiate into neuronal, pulmonary, pancreatic beta cell islets, corneal epithelial cells, and cardiomyocytes in vivo and in vivo, so they can be used for the treatment of numerous damaged tissues and disorders degenerative diseases. MSCs residing in bone marrow are also designated as stromal cells and their well-differentiated progeny located in perivascular niches have the ability to regenerate medullary stroma, osteocytes, chondrocytes, adipocytes, blood vessels and myocytesin vivo and in vitro; given to this cell type a wide potential in clinical practice.
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Dear Carlos,
- Were the MSCs you mentioned derived from a single cell or were they tested from a mixed population.of cells? Do they have the same characteristics in all situatios: cryopreservation, progression factors, inductive factors, growth on plastic, same appearance, etc. Only when cells share EXACTLY the same characteristics can one assume they are the same cell.
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