Is HDAC overexpressed in cervical cancer? What is the mechanisms of oncoprotein E6 and E7 of HPV influence the activity of HDAC?
Dear Abi,
To answer this question beyond a single research article, I strongly recommend you to search the NCBI GEO profiles database, it is a free database.
For example, I did a search for HDAC9 (you can try other types) and cervi* (truncated term so I can get cervix, cervical) and there seems to be a sligh upregulation when compare to normal samples and as one moves towards late stages (high grade vs invasive) http://www.ncbi.nlm.nih.gov/geo/tools/profileGraph.cgi?ID=GDS3292:205659_at
However, did not find significant differences in terms of expression of HDAC9 btween HPV-positive and HP-negative samples for squamous cell carcinoma http://www.ncbi.nlm.nih.gov/geo/tools/profileGraph.cgi?ID=GDS1667:205659_at
Abi Sofyan Ghifari wrote:
> What is the mechanisms of oncoprotein E6 and E7
> of HPV influence the activity of HDAC?
In my RSS collection there was an article
with this abstract.
"[...] Our findings describe a novel role of the E7
oncoprotein in activating the function of a
key transcription factor mediating hypoxic responses
by blocking the binding of HDACs.
Cancer Res; 71(3); 1187–95"
http://cancerres.aacrjournals.org/content/71/3/1187.short?rss=1
Regards,
Joachim
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