I am currently undertaking my PhD on drug combination against nasopharyngeal carcinoma, NPC. I am screening various targeted therapies and chemotherapies with aim to come out with the best synergism activity. I have found possible drug combination that synergized but what about drugs that antagonized each other? I would like to know if antagonized combinations are worth to be looked into? It may help to further understand the mechanisms of NPC other than just focusing solely on synergism.
Thanks for the paper suggestion Ali. I have more than 10 drugs (targeted therapies n chemodrugs) with top 3 drugs selected as core drug in combination with the rest of the drugs based on their selectivity index. I tested on 2 NPCs cell lines so far. Narrowing down the best combination with high synergism on both cell lines. It's just that I feel it would be such a waste of months hardwork if i just ignore the antagonize combination although my study aims to determine best combination. The only thing that I can think of for now is antagonized combination also provide in depth information on NPCs survival/resistance mechanism. Negative results are still results.
Also plz see this paper.
Article Synergistic and Antagonistic Drug Combinations Depend on Net...
Thanks Ali. I have just read the same paper yesterday after further reading based on the paper you suggested. It gave me some idea for my conference paper. That paper really helped a lot on explaining the importance of cataloging both synergism and antagonism combinations in order to fully understand the network/mechanisms in cancer biology.
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